COVID-19

4 December, 2021

Omicron variant of SARS-CoV-2 harbors a unique insertion mutation of putative viral or human genomic origin

The genetic similarity to the common cold virus (also a SARS virus) found in omicron may explain why omicron, unlike the previous variants, infects younger people AND seems to be less virulent.

 

Inflammatory Markers and ACS Risk as Measured by the PULS Cardiac Test: a Warning

No wonder Twitter users are so ignorant. This article is an abstract published in the scientific journal, Circulation. When twitter users sought to retweet/forward this abstract, the fools at twitter censored it. Never assume that people who read twitter are “well-rounded” and familiar with any particular issue. Shameful.

3 December, 2021

This Virus Is a Shape-Shifter!” – New Research Details How COVID Variants Are Evolving New Ways To Evade Vaccines

“For some of the highly mutated variants, serum from single-dose vaccine recipients completely lost the ability to neutralize the virus. In samples taken from people who had received a second dose of vaccine, the vaccine retained at least some effectiveness against all variants, including some extensively mutated pseudotypes.”

The quote above, taken from the article, suggests why boosters may be necessary to counteract new variants as they occur.

The evolution of the mechanisms of SARS-CoV-2 evolution revealing vaccine-resistant mutations in Europe and America

I”ll paraphrase the gist of this paper: existing vaccines are designed to select against specific variants of a virus. This selection pressure will, over time reduce the population of this variant. However, the course of viral evolution is to constantly mutate and create different variants against which the existing vaccines are less effective. This is what is happening the SARS-Cov-2 virus. The original virus has been long removed from population of SARS-Cov-2 viruses and replaced by  subsequent variants.

This CDC publication, which spells out the classification of SARS-Cov-2 variants, is very helpful.

29 November, 2021

No significant difference between vaccinated and unvaccinated people in transmitting the virus that causes COVID-19 (i.e.,  the SARS-Cov-2 virus)

Here is the conclusion quoted from the paper:

Conclusions As this field continues to develop, clinicians and public health practitioners should consider vaccinated persons who become infected with SARS-CoV-2 to be no less infectious than unvaccinated persons. These findings are critically important, especially in congregate settings where viral transmission can lead to large outbreaks.

This is yet another study demonstrating that vaccination DOES NOT prevent transmission of SARS-Cov-2 virus. Said another way, vaccination does not afford protection to others from being infected with SARS-Cov-2.  The vaccine’s only effect is to render the disease less severe in vaccinated individuals.

But, at the risk of beating a dead horse, the argument that we need to vaccinate all people to prevent transmission is not borne out by the science.

Meanwhile, the search for existing medications that can be repurposed to treat COVID-19 continues. For example, here’s a very recent study in which the researchers analyzed data from more than 944,000 U.S. veterans who had at least one COVID-19 test between February 2020 and February 2021, including more than 2,200 who had been prescribed disulfiram for alcoholism.

The study found that those taking disulfiram had a 34% lower rate of COVID-19 infection than those who weren’t taking the drug. None of the infected veterans who were taking disulfiram died, compared with 3% of infected veterans who weren’t taking the drug.

28 November, 2021

A new SARS-Cov-2 variant has been discovered in South Africa. The WHO organization has rated this variant (named Omicron) as “concerning”.

COVID-19 caused by this variant, presents with extreme fatigue along with mild headaches. In addition, there is typically no loss of taste or smell, low or no fever, no sore throat, and no chest congestion. Because of the very mild symptoms, physicians treating Omicron patients have raised concerns that it’s been missed in other countries and may be more widespread than we think. So far the typical patient is a male under the age of 40. Whether this bears out after more patients are studied is up in the air. This is concerning, however, because, though unconfirmed, this may indicate that the Omicron variant presents a higher risk to young people than did the earlier variants.

Also noted is that the symptoms are mildest in vaccinated patients – even those with only 1 course.

Now, for some technical fun:

  1. This variant exhibits 50 mutations, 32 of which occur on the mRNA that code for the spike protein.  Interestingly, when tested, it appears that the Omicron variant exhibits a phenomenon called “S-gene dropout” or more correctly “S-Gene Target Failure” (SGTF). This is how the Omicron variant is distinguished from other SARS-Cov-2 variants, namely, the other variants do not exhibit SGTF.
  2. To understand how this variant may be milder than previous ones, here’s a high-level overview of how COVID-19 behaves. The spike protein (found on the surface of the viral capsid) is the protein that binds to the ACE-2 enzyme in the target cell’s wall (usually endothelial cells which are found throughout the body, notably in the lungs and vascular tissues). When a SARS-Cov-2 virus binds to an ACE-2 receptor its effect, among others, is not unlike that of an ACE-2 inhibitor (e.g., Lisinopril) and that is to inhibit the production of angiotensin II thus lowering blood pressure. A dangerous side-effect of reduced angiotensin II, however is the suppression of glutathione production thereby increasing the risk of runaway oxidative stress. When the endothelial cells of blood vessels undergo oxidative stress because of COVID-19 they die and trigger all sorts of problems but especially thrombotic and  immnological cascades.
  3. What follows is pure speculation on my part. So, with #2 in mind of the 32 mutations in the spike protein, 10 are found in its Receptor Binding Domain (RBD), the part of the spike protein that actually attaches to the ACE-2 receptor. RBDs are highly conserved which means that mutations in an RBD are often deleterious in some way.  This is because an RBD and the protein to which it binds is analogous to a lock and key. The RBD and its protein must match exactly. If it doesn’t, then the binding is either non-existent or weak. This may be the case with the Omicron variant. Its RBD-ACE-II binding may be weakened by the 10 RBD mutations leading to inefficient angiotensin-II suppression and subsequent downregulation of Glutathion. This may explain the more mild symptoms exhibited by Omicron-caused COVID-19.

What can you do in anticipation of this virus infecting you (and it almost surely will – vaccinated or not). Please think about adopting the I-MASK+ protocol (see here). Personally, I [still] take a modified version of I-MASK+, specifically …

  1. Take at least 5000 IUs of vitamin D3 daily.
  2. Take 600 mg of Quercetin in the morning and the evening.
  3. Take at least 50 mg of Zinc daily. Take the Zinc along with the morning dose of Quercetin.
  4. Take 750 mg of Vitamin C daily.

NOTE: If your physician (or state) permit, then substitute ivermectin for quercetin. See the link above for details.

If you notice symptoms (fatigue, headache, low fever, loss of smell, taste, chest congestion, etc.,) call your physician ASAP – especially if you’re over the age of 65. Also, think about taking N-Acetyl Cysteine (NAC). NAC has the effect of replenishing the glutathion pathway and thereby reducing the effects of oxidative stress.

UPDATE I:

What makes the Omicron variant so dangerous? It’s not clear that it does! The South African medical association which first found the variant says Omicron causes ‘mild disease.’ “It presents mild disease with symptoms being sore muscles and tiredness for a day or two not feeling well. So far, we have detected that those infected do not suffer loss of taste or smell. They might have a slight cough. There are no prominent symptoms. Of those infected some are currently being treated at home.”

UPDATE II:

The normal evolution of a virus is to become attenuated, i.e., more infectious, less virulent.

20 November, 2021

Roundup of Ivermectin Studies

Each of these studies links to a discussion page which extracts key outcomes and offers links to html and pdf versions of the full text. This site has another 35 ivermectin studies with different inclusion criteria, subanalyses by every variable under the sun, responses and counterresponses to everyone who disagrees with them about every study, and they’ve done this for twenty-nine other controversial COVID treatments.

Putting aside the question of accuracy and grading only on presentation and scale, this is one of the most impressive attempts of scientific communication I have ever seen. Consider that the WHO and CDC get billions of dollars in funding yet neither of them has been able to communicate their perspective anywhere near as effectively. Even an atheist can appreciate a cathedral, and even an ivermectin skeptic should be able to appreciate this website.

— michael

19 November, 2021

Some links dealing with the risk COVID poses to children.

Overall, school-aged children have a COVID recovery rate of 99.997%—better than their mortality risk from the seasonal flu. This one fact alone should make it clear to everyone that our kids are generally safe. As long as they don’t have any pre-existing conditions that make them more likely to have severe problems with COVID, their risk is minimal.

In fact, when it comes to COVID, age has more impact on one’s risk of dying than vaccination. According to a recent study from the UK, unvaccinated children are safer from COVID than even vaccinated adults of any age.

COVID-19 isn’t nearly as deadly to children as other past viruses that didn’t prompt fear-mongering politicians and scientist-bureacrats  to impose mandates on kids to keep them out of public places.

“Swine flu, for example, resulted in roughly 19.5 million infections in children between the ages of 0-17 from April 2009-2010, causing 1,282 deaths,” notes the Foundation for Economic Education. “This means it had an infection fatality rate of 0.0066 percent.”

What about COVID, you ask? “COVID-19, on the other hand, resulted in nearly 27 million infections in children between February 2020 and May 2021, causing 332 deaths. This means COVID had an infection fatality ratio of 0.0012 percent.” More succinctly, over a similar timespan, the Swine flu exhibited an Infection Mortality Rate (IMR) in children five times higher than COVID-19 over an equivalent time-span. Put another way, the 1,282 lives swine flu claimed in that single year is nearly double the 645 COVID deaths over a similar period of time.

17 November, 2021

A Scoping Review of the Pathophysiology of COVID-19 (Marik, et al)

NOTE: A ‘scoping’ review is a detailed review of a issue of interest but that is bounded by a scope. In this case, the review restricts (aka scopes) the content of the paper to three aspects of the COVID-19 pathophysiology:

  1. Pulmonary damage due to the inflammation attendent with MAS.
  2. Systemic Endotheliatis with typical early pulmonary involvements.
  3. Mast cell degranulation and its attendent hyper-inflammatory state.

Well worth your read if you are a medical professional.

15 November, 2021

Florida COVID Summit Talks (International Alliance of Physicians)

Why are Covid cases spiking (Brian C. Joondeph, M.D.)

 

13 November, 2021

Dr. Scott Atlas unloads on Fauci, Birx, Redfield in forthcoming memoir: ‘I was disgusted’ (Fox News)

The FDA is Holding Up Potentially Life-Saving COVID Treatments (Foundation for Economic Education)

UPDATE: To be fair, if highly effective treatments are available, the case for mass vaccination collapses.

 

11 November, 2021

Minnesota governor falsifies COVID-19 deaths to justify shutdown (John Hinderaker, Powerline)

To date, 182 million people have been fully vaccinated in the U.S by one of three vaccines: Pfizer, Moderna, and Johnson and Johnson (J&J). The latest studies show that these three vaccines have been remarkably effective in reducing the mortality from the Corona virus. However, until now few studies have addressed the question of what effect, if any, have these vaccines had on non-COVID-19 mortality.  To answer this question, a new study just released by the CDC addresses this question explicitly. As described in the study, the authors write,

Although deaths after COVID-19 vaccination have been reported to the Vaccine Adverse Events Reporting System, few studies have been conducted to evaluate mortality not associated with COVID-19 among vaccinated and unvaccinated groups.

To this end, the researchers studied 11 million patient records from seven health-care organizations for the period between December 14, 2020 and July 31, 2021. The findings was very clear. The authors state:

In a cohort of 6.4 million COVID-19 vaccinees and 4.6 million demographicallysimilar unvaccinated persons, recipients [of the COVID-19 vaccines] had lower non-COVID-19 mortality risk than did the unvaccinated comparison groups.

So, this study answers the question, is there an increase in mortality that is missed associeated with these vaccines? Asked another way, are these vaccines associated with non-COVID-19 deaths that we are not observing?

Here Are the Arguments That Persuaded the 5th Circuit To Block OSHA’s Vaccine Mandate for Private Employers (Jacob Sullum, Reason)

CDC’s Director Implies That Face Masks Are More Effective Than Vaccines at Preventing COVID-19 Infection (Jacob Sullum, Reason)

This is one of the more absurd studies claiming ostensible support for masking. I remarked as much on this to my daughter-in-law when she brought this study to my attention. Mr. Sullum, the author, rightly points out that the investigators DID NOT measure infectivity. They measure the ability of masks to filter expiration droplets.

She is yet another bureaucrat physician whose authority has vanquished her ability to think critically. Anthony Fauci is, of course, the quintessential example of this phenomenon.

Getting Through the Next Six Months of COVID (Thomas T. Siler, MD, American Thinker)

When Will The CDC Correct Its COVID Death-Counts, As Italy Just Did (Tyler Durden, Zero Hedge)

Whether (1) vaccinations and/or (2) mask-wearing should be mandated are political questions. Rephrased as scientific questions

For a given population, do mandatory vaccination and mandatory mask policies reduce the pathological consequences of SARS-Cov-2 infection over that of voluntary policies?

As a general rule, the latest science supports neither of these two policies.

8 November, 2021

The Pharmacodynamics of Ivermectin and Pfizer’s PAXLOVID. See this video

30 October, 2021

I-MASK+ Prevention & Early Outpatient Treatment Protocol for COVID-19 and the related MATH+ Hospital Treatment Protocol for COVID-19

27 October, 2021

Masks! – Clearing Up the Confusion (Pierre Kory)

The link below is from Kory’s article above and addresses why masks are not effective prophylactically (the spread of the virus is principally via aerosolized droplets hundres to thousands of times smaller that the best commercial masks).

Airborne Transmission of SARS-Cov-2 (Morawska and Milton, Clinical Infectous Diseases, 6 July, 2020)

Then there is this – the now famous (and compelling) Denmark study which concluded that…

The recommendation to wear surgical masks to supplement other public health measures did not reduce the SARS-CoV-2 infection rate among wearers by more than 50% in a community with modest infection rates, some degree of social distancing, and uncommon general mask use

16 October, 2021

Do masks work? Consider the size of the virus relative to pore size of a surgical mask. The COVID virus is 50-140 nm, while the pore size in standard surgical masks is 300 nm to 10,000 nm. This is using a chain-link fence to stop mosquitoes.