My COVID-19 Prophylactic Supplements

This post provides the scientific rationale behind the five supplements that I take to prevent infection by the SARS-Cov-2 virus and its associated disease, COVID-19. If you’re interested in starting a protocol like this do not do so without letting your physician know what you’re doing. You can download a PDF copy of this post here – Quercetin and Vitamin C

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Quercetin and Vitamin C

Frontiers in Immunology, 19 June, 2020, Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19)

Here’s a background article on quercetin’s zinc inonophoric activity.

Zinc

When used in combination, quercetin, zinc prevents corona virus (SARS-Cov-2) replication. Quercetin’s role in this treatment is to increase the concentration of intracellular zinc. It does this by chelating positively charged zinc ions and transporting them across the cell membrane into the cell. If the cell is infected with SARS-Cov-2 the zinc will disrupt the enzyme (RNA-dependent, RNA polymerase) responsible for replicating the viral RNA. Note that the concentration of zinc inside a cell is normally very low even in the presence of high concentrations of Zn in the serum. Hence the use of Quercetin as a zinc ionophore..

Vitamin D3

This is a very large retrospective study (365,000 patients) over 9+ years: Vitamin D Status and Risk of All-Cause and Cause-Specific Mortality in a Large Cohort: Results From the UK Biobank.

With this study in mind, here is a wide ranging and detailed article on Vitamin D –Immunologic Effects of Vitamin D on Human Health and Disease. One of the most interesting topics in this long article was the discussion of Vitamin D’s effect on endothelial function and vascular permeability. Here the authors point out that Vitamin D exhibits both direct and indirect modulatory effects, the latter by upregulating the transcription of certain genes that produce endothelial nitric oxide.

N-Acetylcysteine (NAC)

Here’s a video excerpt from the on-line CME course I took. The instructor discusses the biochemical pathways that can lead to oxidative stress and how NAC (a precursor to Glutathion) acts to ameliorate oxidative stress. This video is valuable in that the instructor reviews a couple of very interesting articles about the applicability of NAC to COVID-19.

This related article appeared in in Circulation about 3 years ago, “Potent Thrombolytic Effect of N-Acetylcysteine on Arterial Thrombi. Of course, COVID-19 was not an issue then but given COVID-19’s pathogenesis, NAC appears relevant.

Finally, I found these two articles very informative for me. If you’re a physician reading this then consider these two a refresher. However, not having a clinical background. I include them only because they really helped me understand the issues more deeply.

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First Annual Trouthaven Mudbug Boil

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Some Selected Game Camera Pics

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Cabin Opening 2019

Trouthaven (Click to Enlarge)

Our Cabin at Trouthaven (July, 2018)

We’re ready for the season.

… and ready for you (Click to Enlarge)

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We Have the Best Neighbors

Aren’t neighbors swell? Received this bill for services rendered this afternoon. You’ll agree that services such as these are indicative of kindness and charity toward neighbors. However, my only complaint is the clearing of stream-bed objects that snag flies. It’s important to note that I KNOW each object’s location (and I may have even put them there) – hence my huge collection of salmon-flies, wooly-buggers, rubber legged nymphs of sundry varieties.

As Andy correctly estimates, these accumulate hundreds, may thousands, of dollars of flies. Flies that are now no longer available for harvesting. Given this loss, I think we may be able to reach an accomodation. More imporantly, wine, Bulleit bourbon, and good company will surely lead to some agreement on this matter.

Here’s Andy’s letter in full:

Dear Mr Peterson,

We have took it upon ourselves to prepare your Rock Creek fishing beat for your upcoming arrival. Therefore the following bill is being passed on for your remittance at your earliest convenience. We are sure that all of our grueling work will be up to your standards!

1- stream bed branch removal. This was done to save you hundreds of dollars in fancy fish catching flies throughout the season. We feel that $50 is more than fair for this service.

2-whitefish relocation. We painstakingly caught and moved (typically 5 to 10 feet from original location) close to a dozen pesky whitefish from the beat. This service is typically $10 per fish, but due to the amazing weather, we will only charge $8 per fish.

3-trout count / size survey. We also took the time to catch, count, and acquire an approximate size on as many trout as possible. We figure that this was an integral part of maintaining a healthy beat, so the cost reflects at $150, but due to the nice weather, we are only billing $100.

We look forward to meeting up with you as soon as you land at the creek to receive payment, and possibly drink some red wine!

Sincerely,

Your fishy friend,

Andy

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Congratulations Missoula

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August Fishing on Rock Creek

PRO TIP 1: qlways move upstream when fishing. Fish ALWAYS face into the current so when you move upstream they are not as likely to sense your presence.

PRO TIP 2: the fish are all over the place. There is usually no need to wade to the middle of the river. The exception to this rule is when you are hunting fish. This is my preferred method of fishing. I’ll sit and watch the river till I see a trout rise then stalk to within casting range. I only move out into the middle when necessary to reach a rising fish.

PRO TIP 3: Look for lines of bubbles on the surface. These signal the presence of a current seam and the fish will hang in the water on the slower side of the seam only moving across the seam into the faster water when food (or your fly!) drifts by. So, fish the fast water along the seam by putting your fly as close to the bubbles (on the fast side) as you can.

PRO TIP 4: ignore deep water unless you see fish rising. Instead, fish the edges of the deep water where the bottom drops off. Feeding fish like to say close to the bottom where the Osprey can’t see them. The edges of the deep water allows them to stay close to the bottom, close to the surface, with a quick escape to the deep water when you come sloshing by.

PRO TIP 5: here’s how to spot feeding trout. Look into the water and focus your eyes on the bottom. Keep staring at the bottom because sooner or later a fish will expose itself by rolling on its side to grab a fly or, more commonly, opening its mouth to suck in a nymph. In the latter case, you should see the which flash of its gums.

Rock Creek Hatch Chart courtesy of Rock Creek Trout Bums

Must have Dry Flies for August on Rock Creek

 

PERSONAL NOTE: of these four flies, my personal favorite (because it’s been the most productive for me) is the Purple Haze, especially in the morning before the sun hits the water. In the evening a lighter pattern is often more productive – the Spruce Moth or an Elk Hair Caddis are good flies for this time.

Of course, what’s summer fishing without a productive hopper strategy: my recommendation is to use any hopper imitation with a dropper. This is almost always a good bet midday. As for the combo pictured in this image, I would rather recommend you use size 18 bead-head copper john or bead-head pheasant tail for the trailer and any size 10 or larger hopper with a foam body and wiggly rubber legs.

 

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The Tiger Trout of Rock Creek

One of the rarest fish in the world.

 

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My First Elk Sighting – Rock Creek, MT

Well, it seem many of the residents here in Trouthaven have seen Elk down here in Trouthaven. Most of the Elk are careful to stay high in the surrounding Sapphire (constitute the West side of Rock Creek canyon) and the John Long mountains (being the East side of Rock Creek) making the sighting of one (or more) quite an event.

I just saw my first elk (3 actually) on the West side of Rock Creek near the Giant’s Toe (a.k.a. the Big Rock). Sadly, they skedaddled up the mountain and were gone from sight before I could get my camera on ’em.

Anyway, Marty and Laurie took pictures of two elk in Harry’s Flat a few years ago. Over ten years ago, Don and Bonny took pictures of 3 elk in their yard. Just a few weeks ago, Andy and Jaycee had two young bull elk trot across their property and go up into the Sapphires. Shortly thereafter, Lynn, Gail, and I were saw a small herd way up in a meadow near Quigley.

So, they are around here but seem to avoid humans – much more so than bears and moose.  As a matter of fact, it seems that more people see mountain lions than elk down here on the river. The montana fish and game biologists cataloged a herd of about 600 elk in the Welcome Creek area of Rock Creek in the late 90s. Since then, most of the heard has moved South to the Stoney Creek drainage leaving about 60 to 100 up here between Trouthaven and Welcome Creek.

The Montana biologists note that a pack of Wolves have moved into the Sapphires and much of the Sapphire herd has left the high range to graze in and near Stevensville – just due West of us about 10 miles.

 

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Updated, Improved Shower Enclosure

I can tell you that there are few things in life more refreshing than an outdoor shower after a ‘hard’ day fishing in 90 deg weather (or, say. whittling down the ever growing honey-do list). Our shower, shown here, is huge (8′ by 4′), has hot and cold running water, clothes and towel racks, and a composting toilet.

Sadly, there’s a mountain peak immediately to the South that affords a view down into the enclosure from 5,500 ft and 3 miles away.

This year I’ve modified the enclosure, adding corrugated galvanized metal paneling over the original cedar planks. Gail and I both think it looks more rustic, but also gives more privacy.

Here’s the inside: note I retained the cedar planks. The corrugated panels are not visible from the inside. By the way, the shower curtain is, strictly speaking, not necessary (the door blocks any line of sight. Why, do you ask? Well, it’s got pics of moose, bears, and fish AND for those of you who do calisthenics while showering, the curtain keeps water off your clothes.

 

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